If you are looking to order super cardarine uk, understanding the distinction between GW0742 and its better-known counterpart Cardarine (GW501516) is essential. Both are PPARδ agonists, but GW0742 offers significantly higher receptor selectivity and potency—an important factor for researchers comparing formulations before reaching competitor cart pages.
This guide provides a comprehensive breakdown of GW0742 purity standards, available formulations, and sourcing considerations for researchers across the UK.
Understanding GW0742: The Ultra-Selective PPARδ Agonist
GW0742 (also known as GW610742) is a potent and highly selective agonist of the peroxisome proliferator-activated receptor delta (PPARδ). Developed by GlaxoSmithKline alongside GW501516, this compound was identified through structure-guided lead optimization as one of the first truly selective PPARδ agonists.
Key Product Specifications
- CAS Number: 317318-84-6
- Molecular Formula: C₂₁H₁₇F₄NO₃S₂
- Molecular Weight: 471.49 g/mol
- Purity Standard: ≥98% HPLC-verified (up to 99.99% from premium suppliers)
Potency and Selectivity
GW0742 demonstrates exceptional receptor selectivity:
| Receptor | EC₅₀ | Selectivity Ratio |
|---|---|---|
| PPARδ | 1 nM | 1× (baseline) |
| PPARα | 1 µM | 1,000× less selective |
| PPARγ | 2 µM | 2,000× less selective |
This 1000-fold selectivity over the other human PPAR subtypes makes GW0742 a valuable research tool for studying PPARδ-mediated biology.
Structural Comparison: GW0742 vs Cardarine (GW501516)
Despite being structural analogs differing by a single atom , GW0742 offers distinct advantages for certain research applications:
GW0742 delivers a noticeably stronger conditioning effect per milligram versus Cardarine, with more robust lipid improvements and easier stacking protocols .
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Available Formulations: Capsules vs Powder
Capsules (10mg, 20mg, 50mg)
Capsules offer pre-measured dosing convenience, making them ideal for researchers requiring consistent unit dosing. Premium capsules are manufactured with HPLC-verified compound and pharmaceutical-grade excipients.
| Experience Level | Recommended Dose |
|---|---|
| Beginner | 4-7 mg daily |
| Intermediate | 8-10 mg daily |
| Advanced | 10-15 mg daily |
Cycle Length: 6-12 weeks, with a 4-week minimum washout between cycles.
Powder Form
Powder offers flexibility for custom dosing and is available in research quantities from 1mg to bulk volumes .
Storage Requirements
| Form | Condition | Duration |
|---|---|---|
| Powder | -20°C | 3 years |
| Powder | 2-8°C | 2 years |
| In solvent | -80°C | 1 year |
| In solvent | -20°C | 1 month |
Solubility: GW0742 is soluble in DMSO (94 mg/mL), ethanol (44 mg/mL), and is insoluble in water.
Certificate of Analysis: What to Verify
When sourcing GW0742, the Certificate of Analysis (COA) should confirm the following:
- HPLC purity (≥98% minimum; ≥99% from premium suppliers)
- Mass spectrometry confirmation (molecular weight 471.49 g/mol)
- Batch-specific traceability
- Storage recommendations matching the product datasheet
Red flags: Generic COAs without batch-specific referencing, missing chromatograms, or purity figures quoted without supporting data.
Common Research Applications
GW0742 is utilized in the following research areas:
- Metabolic Regulation: Fatty acid beta-oxidation enhancement and lipid profile studies
- Cardioprotective Research: Anti-inflammatory and ischemia-reperfusion injury studies
- Endurance and Exercise Adaptation: Skeletal muscle oxidative capacity research
- Anti-Inflammatory Studies: NF-kB pathway modulation
GW0742 vs Cardarine: Which to Choose?
Choose GW0742 if:
- Maximal PPARδ activation is required—competitive endurance phases or advanced recomp
- Lower mg-per-day dosing with higher receptor binding is preferred
- Prior Cardarine protocols felt underwhelming at standard doses
Choose Cardarine if:
- Reliance on community-vetted protocols and larger real-world sample size is preferred
- Cost-per-cycle is a concern
- Standard endurance, conditioning, or lipid management goals without needing to push dosing boundaries
Conclusion
GW0742 represents a significant advancement in PPARδ research compounds, offering exceptional selectivity and potency for researchers. For those looking to order super cardarine uk or source pure gw0742 research chemical uk, understanding the technical specifications and quality documentation is essential. Always source from suppliers who provide batch-specific COA verification with independent HPLC testing, and ensure proper storage protocols are followed to maintain compound integrity.